Result: A total of 27 potential therapeutic targets were screened out. Seven hub targets (PPARA, CAT, MAPK14, SQSTM1, HMOX1, GRB2, and GSR) were identified. Functional and pathway enrichment analysis indicated that these 27 putative targets exerted therapeutic effects on oocyte aging by regulating signaling pathways (e.g., PPAR, TNF, apoptosis, necroptosisn, prolactin, and MAPK signaling pathway), and are involved oxidation-reduction process, mitochondrion, enzyme binding, reactive oxygen species metabolic process, ATP binding, among others. In addition, five densely linked functional modules revealed the potential mechanisms of CoQ10 in improving aging-related deterioration of oocyte quality are closely related to antioxidant, mitochondrial function enhancement, autophagy, anti-apoptosis, and immune and endocrine system regulation. The molecular docking study reveals that seven hub targets have a good binding affinity towards CoQ10, and molecular dynamics simulation confirms the stability of the interaction between the hub targets and the CoQ10 ligand.
Conclusion: This network pharmacology study revealed the multiple mechanisms involved in the anti-aging effect of CoQ10 on oocytes. The molecular docking and molecular dynamics simulation provide evidence that CoQ10 may act on these hub targets to fight against oocytes aging.
With so many anti-aging products available, it can be difficult to know what to use. Shopping for an anti-aging skin care product can feel like a hit-or-miss experience. With so many choices, it can be difficult to know which products to choose. These dermatologist tips can help you shop with confidence.
Start with sunscreen and moisturizer. Dermatologists agree that sunscreen and moisturizer are the two most-effective anti-aging products you can buy. Using these every day can make a noticeable difference.When shopping for sunscreen, select one that offers all of the following:Broad spectrumSPF 30 (or higher)Water resistanceAn anti-aging moisturizer helps to minimize fine lines. It is so effective that moisturizer is the secret ingredient in many anti-aging products.Using a moisturizer with sunscreen is fine. Just be sure that the product offers broad-spectrum coverage and an SPF of 30 or higher.If you will spend time outdoors during the day, you should apply a sunscreen that offers broad-spectrum protection, SPF 30 (or higher), and water resistance. Be sure to reapply your sunscreen every two hours while outdoors.
Researchers have even concluded that eating fruits and veggies is the safest and healthiest way to combat dull complexions and fine lines. Ready to glow? Here are 10 of the best anti-aging foods to nourish your body for a glow that comes from within.
Watercress acts as an internal skin antiseptic and increases the circulation and delivery of minerals to all cells of the body, resulting in enhanced oxygenation of the skin. Packed with vitamins A and C, the antioxidants in watercress may neutralize harmful free radicals, helping to keep fine lines and wrinkles away.
Carotenoids are plant pigments responsible for the bright red, yellow, and orange colors you see in many fruits and vegetables. They have a variety of anti-inflammatory properties and may help protect skin from sun damage, pollution, and environmental toxins.
Many nuts (especially almonds) are a great source of vitamin E, which may help repair skin tissue, retain skin moisture, and protect skin from damaging UV rays. Walnuts even contain anti-inflammatory omega-3 fatty acids that may help:
The orange color of the sweet potato comes from an antioxidant called beta-carotene which is converted to vitamin A. Vitamin A may help restore skin elasticity, promote skin cell turnover, and ultimately contribute to soft, youthful-looking skin.
Pomegranates have been used for centuries as a healing medicinal fruit. High in vitamin C and a variety of potent antioxidants, pomegranates may protect our body from free radical damage and reduce levels of inflammation in our system.
Dr. Christopher J. Riegel of The Riegel Center in Plano, Texas is a leading specialist in hormone replacement technology, an innovator who develops his own HRT formulas to meet the specific needs of his patients. Further focusing on specialized types of hormones called bioidentical for their exact molecular match to the hormones produced by the body, Dr. Riegel combined his expertise in gynecology and endocrinology and applied these to anti-aging and wellness.
Rejuvime Medical is a wellness and anti-aging clinic which offers bioidentical hormone replacement therapy and other services at its 3 locations in Baton Rouge, Metairie, Slidell, and Shreveport, Louisiana. The medical director, Dr. Jonathan Weiler, is a board-certified plastic surgeon. Women and men seeking hormone replacement therapy travel from New Orleans and throughout the state to Rejuvime Medical, which also offers blood testing and cosmetic injectables to patients.
Most cases can be cured with a high dose of antibiotics, taken for 7 to 14 days, and then lower doses for several weeks. You may also need drugs to help with pain or discomfort. If your PSA level was high, it will likely return to normal once the infection is cleared up.
Antibiotic treatment over a longer period of time is best for this type. Treatment lasts from 4 to 12 weeks. This type of treatment clears up about 60 percent of cases. Long-term, low-dose antibiotics may help relieve symptoms in cases that won't clear up.
There are several different treatments for this problem, based on your symptoms. These include anti-inflammatory medications and other pain control treatments, such as warm baths. Other medicines, such as alpha-blockers, may also be given. Alpha-blockers relax muscle tissue in the prostate to make passing urine easier. Some men are treated with antibiotics in case the symptoms are caused by an undetected infection.
Metformin is a commonly used drug for treating patients with Type 2 diabetes. Extensive research has shown that metformin can also be used as an anti-aging therapy. For this reason, many people without diabetes, including Silicon Valley techies, take the inexpensive drug in the hopes it will keep them healthy longer.
Researchers from the Texas A&M University College of Medicine have recently conducted a study that found that 10 weeks of metformin treatment on animal models, starting in late middle age, was sufficient to maintain better cognitive and memory function in old age, thus helping prevent age-related cognitive problems. These findings, published in the journal Aging Cell, show potential evidence for metformin to be used as an anti-aging drug in the non-diabetic population.
In a recent study, our team identified a novel anti-ageing protein, called Gaf1. We found that Gaf1 controls protein metabolism, a process that has been implicated in ageing and disease. We also found that without Gaf1, cells have a shorter lifespan.
We also found that cells lacking Gaf1 are short-lived. As mentioned, TOR signals cells to grow, which contributes to their ageing. But when TOR is inhibited through dietary restriction or drugs, growth is halted and lifespan is extended. Without Gaf1, the growth is not halted and the observed lifespan extension is not taking place fully. In other words, we found a molecule that mediates some of the beneficial effects of dietary restriction.
But where we have an advantage over our mums and grans is we are more likely to have a healthy diet and wear sunscreen, and less likely to smoke, have nine children or work down a pit. For which we have to be grateful. Plus, where anti-ageing products and treatments once extended only to a knob of lard and a sweep of rouge, we have a squillion different products and therapies designed to help our skin age beautifully.
Our skin has three layers: the epidermis, the dermis and the subcutaneous tissue. The simplest way to understand the ageing process is this; the epidermis is the outer most layer, and it thins with age. The dermis provides the structural support, or springiness, via collagen and elastin fibres, and these get tired and wear out with age. The subcutaneous tissue provides the fat cells that keep our faces plump. We lose these cells as we age, and so our faces sag. It all conspires together to create wrinkles. So far, so depressing? It gets worse.
Our skin quality deteriorates when the molecules within our skin cells are attacked by free radicals and left in a damaged state. Free radicals are unstable molecules in our environment and can be caused by, for example, pollution, cigarette smoke and herbicides. Exposure to ultraviolet light, UVA and UVB rays from sunlight causes immense damage alone, with some reports suggesting it causes up to 90% of the symptoms of premature ageing.
Before the age of 30 our bodies produce enough anti-oxidants to be able to cope with the onslaught of free radicals. After that, we could do with a bit of help. And of course, if you want to keep chemical nasties away from your skin a natural anti-ageing product is the best option.
Good question. There are hundreds of anti-ageing creams, serums, oils and cleansing products available, but only some of them can claim to be natural. As with all natural products, a natural anti-ageing product will not contain potentially harmful ingredients such as phthalates, sulfates, parabens or synthetic fragrances. Depending on the product, its key ingredients may also be organically derived, suitable for vegans, free from petroleum-based ingredients and of course, the best will not be tested on animals. The packaging may be recyclable or even made from recycled materials. 2b1af7f3a8