Onoue T, Nakajima M, Harada Y. Pharmacokinetics of nanoparticles and nanosuspensions: New insights into the relationship of particle size and in vivo performance. Adv Drug Deliv Rev. 2012;64:1095-1194. doi: 10.2174/1871456112909011406. Full text
Nanomedicine-based therapeutics hold great promise for the treatment of several diseases, including cancer, vascular disease, and infectious disease. However, there are still some issues to be addressed such as poor systemic distribution and a lack of targeted delivery of nanomedicines to certain tissues. The pharmacokinetic properties of nanomedicines are still poorly characterized and their mechanisms of action and drug toxicities are not well understood. Therefore, it is necessary to develop biomarkers to monitor and predict the drug toxicity and pharmacokinetic properties of nanomedicines and to improve drug delivery technologies, by which the translational status of nanomedicines will be accelerated. Various nanomedicines with different forms have been developed to address these issues in the last decade. In this review, we have focused on the recent developments of nanomedicines to improve their clinical use, including enhancement of cell permeability and retention, targeting strategies, and formulation technologies.
The article?Nanomedicines: current status and future perspectives in aspect of drug delivery and pharmacokinetics?, written by Young Hee Choi and Hyo?Kyung Han, was originally published electronically on the publisher?s internet portal (currently SpringerLink) on 28 November 2017 without open access.
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